Interactive relations between maternal prenatal stress, fetal brain connectivity, and gestational age at delivery
نویسندگان
چکیده
منابع مشابه
Prenatal maternal stress predicts stress reactivity at 2½ years of age: the Iowa Flood Study.
Prenatal maternal stress (PNMS) predicts psychosocial development in offspring. It has been hypothesized that during PNMS, glucocorticoids pass the placenta, reaching the foetus, leading to a long-term reprogramming and dysregulation of the foetal hypothalamic-pituitary-adrenal (HPA) axis. However, results are inconsistent across PNMS studies. One problem may be the confounding of objective deg...
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Genome-wide transcription data of utero-placental tissue has been used to identify altered gene expression associated with preeclampsia (PE). As many women with PE deliver preterm, there is often a difference in gestational age between PE women and healthy pregnant controls. This may pose a potential bias since gestational age has been shown to dramatically influence gene expression in utero-pl...
متن کاملMaternal and female fetal testosterone levels are associated with maternal age and gestational weight gain
OBJECTIVE Prenatal androgen exposure has been suggested to play a role in polycystic ovary syndrome. Given the limited information on what maternal characteristics influence maternal testosterone levels, and the even less explored routes by which female fetus androgen exposure would occur, the aim of this study was to investigate the impact of maternal age, BMI, weight gain, depressed mood and ...
متن کاملFetal sex-specific differences in gestational age at delivery in pre-eclampsia: a meta-analysis
Background : Pre-eclampsia (PE) is a major pregnancy disorder complicating up to 8% of pregnancies. Increasing evidence indicates a sex-specific interplay between the mother, placenta and fetus. This may lead to different adaptive mechanisms during pregnancy. Methods We performed an individual participant data meta-analysis to determine associations of fetal sex and PE, with specific focus on...
متن کاملGestational age and maternal weight effects on fetal cell-free DNA in maternal plasma.
OBJECTIVE To determine the effects of gestational age and maternal weight on percent fetal cell-free DNA (cfDNA) in maternal plasma and the change in fetal cfDNA amounts within the same patient over time. METHODS The cfDNA was extracted from maternal plasma from 22 384 singleton pregnancies of at least 10 weeks gestation undergoing the Harmony(TM) Prenatal Test. The Harmony Prenatal Test dete...
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ژورنال
عنوان ژورنال: Neuropsychopharmacology
سال: 2021
ISSN: 0893-133X,1740-634X
DOI: 10.1038/s41386-021-01066-7